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SUGIMURA Hideyuki
Department Aoyama Gakuin University Department of Chemistry and Biological Science, College of Science and Engineering Position Professor |
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| Language | English |
| Publication Date | 2023/09 |
| Type | Academic Journal |
| Peer Review | Peer reviewed |
| Title | Access to polysubstituted pyrimidine derivatives via the aza-Diels–Alder reaction of 1,2,3-triazine derivatives and amidines |
| Contribution Type | Collaboration |
| Journal | Tetrahedron |
| Journal Type | Another Country |
| Publisher | Elsevier |
| Volume, Issue, Page | 146,pp.133629 |
| Total page number | 8 |
| Authorship | Lead author |
| Author and coauthor | Minami Usami, Asuka Matsuzawa, Akane Yamada, Ikuo Sasaki, Hideyuki Sugimura |
| Details | The synthesis of highly substituted pyrimidine derivatives by the aza-Diels–Alder reaction of 1,2,3-triazines with amidine derivatives is described. This reaction provided direct access to a wide range of 6-aryl-2-substituted pyrimidine-4-carboxylates in good yields with good functional group compatibility. A broad substrate scope, and the operationally simple, metal-free, and neutral reaction conditions are the prominent features of this method. |