Faculty Information

Official position and committee in Univ.

（Last updated : 2024-08-14 19:17:32）

ABE Fumiyoshi
Department Aoyama Gakuin University Department of Chemistry and Biological Science, College of Science and Engineering

Position Professor

■ Specialization and related fields

Genetics, Cell biology, Biophysics

■ Business career

1.	2010/04～2015/03	Aoyama Gakuin University College of Science and Engineering Department of Chemistry and Biological Science Associate Professor
2.	2015/04～	Aoyama Gakuin University College of Science and Engineering Department of Chemistry and Biological Science Professor

■ Belonging society

1.	1995/03～	Japan Society for Bioscience, Biotechnology, and Agrochemistry
2.	2000/04～	Japan Society for Extremophiles
3.	2000/04～	Yeast Genetics Society of Japan
4.	2012/09～	The Japan Society of High Pressure Science and Technology

■ Official position and committee in Univ.

1.	2019/04/01～2021/03/31	Aoyama Gakuin University Curriculum Coordinator
2.	2021/04/01～2023/03/31	Aoyama Gakuin University Chair

■ Book and thesis

1.	Article	Role of a novel ER-resident glycoprotein Mtc6/Ehg2 in high-pressure growth: Stability of tryptophan permease Tat2 in Saccharomyces cerevisiae. Biosci Biotechnol Biochem. zbae086,pp.1-9 (Collaboration) 2024/06
2.	Article	Mtc6/Ehg2 is a novel endoplasmic reticulum-resident glycoprotein essential for high-pressure tolerance. J. Biochem. mvae035,pp.1-12 (Collaboration) 2024/04
3.	Article	Activation of CWI pathway through high hydrostatic pressure, enhancing glycerol efflux via the aquaglyceroporin Fps1 in Saccharomyces cerevisiae. Mol. Biol. Cell 34(ar92),pp.1-22 (Collaboration) 2023
4.	Article	SOD1 mutations cause hypersensitivity to high-pressure-induced oxidative stress in Saccharomyces cerevisiae Biochim. Biophys. Acta Gen. Subj. 1866,pp.130049 (Collaboration) 2022
5.	Article	Substrate-induced differential degradation and partitioning of the two tryptophan permeases Tat1 and Tat2 into eisosomes in Saccharomyces cerevisiae. Biochim. Biophys. Acta Biomembr. 1864(183858) (Collaboration) 2022
6.	Article	Cellular NADH and NADPH conformation as a real-time fluorescence-based metabolic indicator under pressurized conditions Molecules 26,pp.5020 (Collaboration) 2021
7.	Article	Amino acid homeostatic control by TORC1 in Saccharomyces cerevisiae under high hydrostatic pressure J Cell Sci 133,pp.jcs24555 (Collaboration) 2020
8.	Article	Draft genome sequence of Naganishia liquefaciens strain N6, isolated from the Japan Trench. Microbiol Resour. Announc 9,pp.e00827-20 (Collaboration) 2020
9.	Article	Over-expression of Caj1, a plasma membrane associated J-domain protein in Saccharomyces cerevisiae stabilizes amino acid permeases Biochim. Biophys. Acta 1862,pp.183435 (Collaboration) 2020
10.	Article	A novel ER membrane protein Ehg1/May24 plays a critical role in maintaining multiple nutrient permeases in yeast under high-pressure perturbation Sci. Rep. 9,pp.18341 (Collaboration) 2019
11.	Article	Simulated microgravity triggers characteristic morphology and stress response in Saccharomyces cerevisiae Yeast (Collaboration) 2018
12.	Article	The YPR153W gene is essential for the pressure tolerance of tryptophan permease Tat2 in the yeast Saccharomyces cerevisiae High Pressure Research 38,pp.90-98 (Collaboration) 2018
13.	Article	Functional analysis of human aromatic amino acid transporter MCT10/TAT1 using the yeast Saccharomyces cerevisiae. Biochim. Biophys. Acta 1859,pp.2076-2085 (Collaboration) 2017
14.	Article	Critical role of the proton-dependent oligopeptide transporter (POT) in the cellular uptake of the peptidyl nucleoside antibiotic, blasticidin S Biochim. Biophys. Acta pp.393-398 (Collaboration) 2016
15.	Article	Retrieval of deeply buried culturable fungi in marine subsurface sediments, Suruga-Bay, Japan Fungal Ecol. pp.256-259 (Collaboration) 2016
16.	Article	Involvement of flocculin in negative potential-applied ITO electrode adhesion of yeast cells FEMS Yeast Research pp.fov064 (Collaboration) 2015/09
17.	Article	Retention of chimeric Tat2-Gap1 permease in the endoplasmic reticulum induces unfolded protein response in Saccharomyces cerevisiae FEMS Yeast Research pp.fov044 (Collaboration) 2015/08
18.	Article	Glucosylceramide contained in Koji mold-cultured cereal confers membrane and flavor modification and stress tolerance to Saccharomyces cerevisiae during coculture fermentation Appl. Environ. Microbiol. pp.3688-3698 (Collaboration) 2015/06
19.	Article	Effects of high hydrostatic pressure on microbial cell membranes: Structural and functional perspectives High Pressure Bioscience Basic Concepts, Applications and Frontiers, Subcellular Biochemistry pp.371-381 (Single) 2015
20.	Article	Stress responses of the yeast Saccharomyces cerevisiae under high hydrostatic pressure Stress Biology of Yeasts and Fungi: Application for Industrial Brewing and Fermentation pp.77-92 (Single) 2015
21.	Article	Carbohydrate-active enzymes identified by metagenomic analysis of deep-sea sediment bacteria Extremophiles pp.853-863 (Collaboration) 2014
22.	Article	Functional implications and ubiquitin-dependent degradation of the peptide transporter Ptr2 in Saccharomyces cerevisiae Eukaryotic Cell pp.1380-1392 (Collaboration) 2014
23.	Article	Functional mapping and implications of substrate specificity of the yeast high-affinity leucine permease Bap2 Biochim. Biophys. Acta pp.1719-1729 (Collaboration) 2014
24.	Article	The loss of hydroxyl groups from the ceramide moiety leads to a reduction in the lateral diffusion of membrane proteins in Saccharomyces cerevisiae J. Lipid Res. pp.1343-1356 (Collaboration) 2014
25.	Article	Cold-Adapted Yeasts in Deep-Sea Environments Cold-adapted yeasts: Biodiversity, Adaptation Strategies and Biotechnological Significance (Collaboration) 2013
26.	Article	Development of a highly sensitive yeast bioassay for trichothecene detection Mycotoxins pp.161-170 (Collaboration) 2013
27.	Article	Dynamic structural changes in microbial membranes in response to high hydrostatic pressure analyzed using time-resolved fluorescence anisotropy measurement Biophys. Chem. pp.3-8 (Single) 2013
28.	Article	Effects of high hydrostatic pressure on the dynamic structure of living Escherichia coli membrane: a study using high-pressure time-resolved fluorescence anisotropy measurement High Pressure Research pp.278-284 (Collaboration) 2013
29.	Article	Functional screening for resistance genes against trichothecenes in the library of Saccharomyces cerevisiae deletion mutants Mycotoxins pp.9-15 (Collaboration) 2013
30.	Article	Glycine insertion makes yellow fluorescent protein sensitive to hydrostatic pressure PLoS One pp.e73212 (Collaboration) 2013
31.	Article	Pressure-induced endocytic degradation of the yeast low-affinity tryptophan permease Tat1 is mediated by Rsp5 ubiquitin ligase and functionally redundant PPxY-motif proteins Eukaryotic Cell pp.990-997 (Collaboration) 2013
32.	Article	Soy peptides enhance yeast cell growth at low temperature. Biotechnol. Lett. Biotechnol. Lett pp.375-382 (Collaboration) 2013
33.	Article	Structural and functional implications of the yeast high-affinity tryptophan permease Tat2 Biochemistry pp.4296-4307 (Collaboration) 2013
34.	Article	Eicosapentaenoic acid plays a role in stabilizing dynamic membrane structure in the deep-sea piezophile Shewanella violacea: a study employing high-pressure time-resolved fluorescence anisotropy measurement Biochim. Biophys. Acta pp.574-583 (Collaboration) 2012
35.	Article	New type of pressurized cultivation method providing oxygen for piezotolerant yeast J. Biosci. Bioeng pp.220-223 (Collaboration) 2012
36.	Article	Complete genome sequence of the marine, cellulose and xylan degrading bacterium Glaciecola sp. 4H-3-7+YE-5 J. Bacteriol. pp.4547-4548 (Collaboration) 2011
37.	Article	Complete Genome Sequences of Krokinobacter sp. 4H-3-7-5 and Lacinutrix sp. 5H-3-7-4, polysaccharide-degrading members of the family Flavobacteriaceae J. Bacteriol. pp.4545-4546 (Collaboration) 2011
38.	Article	Different pressure resistance of lactate dehydrogenases from hagfish is dependent on habitat depth and caused by tetrameric structure dissociation Marine Biotechnology pp.137-141 (Collaboration) 2011
39.	Article	High pressure and eukaryotes Extremophiles Handbook pp.687-702 (Single) 2010
40.	Article	Isolation method for high-pressure growth mutants Extremophiles Handbook pp.727-735 (Single) 2010
41.	Article	Overexpression of EAR1 and SSH4 that encode PPxY proteins in the multivesicular body provides stability of tryptophan permease Tat2 allowing yeast cells to grow under high hydrostatic pressure High Pressure Research pp.514-518 (Collaboration) 2010
42.	Article	Overexpression of SNA3 stabilizes tryptophan permease Tat2, potentially competing for the WW domain of Rsp5 ubiquitin ligase with its binding protein Bul1. FEBS Lett. pp.55-60 (Collaboration) 2010
43.	Article	Control of Protein and Sterol Trafficking by Antagonistic Activities of a P4-ATPase and Oxysterol Binding Protein Homologue. Mol. Biol. Cell pp.2920-2931 (Collaboration) 2009
44.	Article	Fluconazole modulates membrane rigidity, heterogeneity and water penetration into the plasma membrane in Saccharomyces cerevisiae. Biochemistry pp.8494-8504 (Collaboration) 2009
45.	Article	Functional interactions between sphingolipids and sterols in biological membranes regulating cell physiology Mol. Biol. Cell pp.2083-2095 (Collaboration) 2009
46.	Article	Identification and characterization of two alternative σ factors of RNA polymerase in the deep-sea piezophilic bacterium, Shewanella violacea strain DSS12. Biochem. Biosci. Biotechnol pp.200-202 (Collaboration) 2009
47.	Article	Interaction of Bap31 and class I MHC molecules and their traffic out of the endoplasmic reticulum J. Immunol. pp.4776-4783 (Collaboration) 2009
48.	Article	Mechanistic role of ergosterol in membrane rigidity and cycloheximide resistance in Saccharomyces cerevisiae. Biochim. Biophys. Acta pp.743-752 (Collaboration) 2009
49.	Article	Sorting defects of the tryptophan permease Tat2 in an erg2 yeast mutant. FEMS Microbiol. Lett. pp.218-227 (Collaboration) 2009
50.	Article	Effects of growth-permissive pressure on the growth and the physiology of Saccharomyces cerevisiae High-Pressure Microbiology pp.167-179 (Single) 2008
51.	Article	Effects of pressure on enzyme function of Escherichia coli dihydrofolate reductase. Biochim. Biophys. Acta pp.1115-1121 (Collaboration) 2008
52.	Article	Global screening of genes essential for growth in high-pressure and cold environments: searching for basic adaptive strategies using a yeast deletion library Genetics pp.851-872 (Collaboration) 2008
53.	Article	Pressure-adaptive differences in lactate dehydrogenases of three hagfishes: Eptatretus burgeri, Paramyxine atami, and Eptatretus okinoseanus. Extremophiles pp.477-480 (Collaboration) 2008
54.	Article	Use of mutant strains of yeast in the brewing industry Encyclopedic Handbook of Beer in Health and Disease Prevention pp.11-21 (Single) 2008
55.	Article	Cloning and functional characterization of the copper/zinc superoxide dismutase gene from the heavy-metal-tolerant yeast Cryptococcus liquefaciens strain N6 Mol. Genet. Genomics pp.403-412 (Collaboration) 2007
56.	Article	Discovery of deep-sea piezophiles, and their adapted enzymes Proceedings for the 4th International Conference on High Pressure Bioscience and Biotechnology pp.114-121 (Collaboration) 2007
57.	Article	Exploration of the effects of high hydrostatic pressure on microbial growth, physiology and survival: perspectives from piezophysiology. pp.2347-2357 (Single) 2007
58.	Article	Induction of DAN/TIR yeast cell wall mannoprotein genes in response to high hydrostatic pressure and low temperature FEBS Lett. pp.4993-4998 (Single) 2007
59.	Article	Physiological effects of increasing hydrostatic pressure in yeast Proceedings for International Symposium on Extremophiles and Their Applications (ISEA2005) pp.262-265 (Single) 2007
60.	Article	Probing for dynamics of amino acid uptake in living yeast using hydrostatic pressure Proceedings for the 4th International Conference on High Pressure Bioscience and Biotechnology pp.134-138 (Single) 2007
61.	Article	Protein adaptation to high-pressure environments Protein Adaptation in Extremophiles. Molecular Anatomy and Physiology of proteins series pp.167-191 (Collaboration) 2007
62.	Article	Regulation and dynamics of yeast tryptophan permeases studied using hydrostatic pressure International Congress Series pp.75-84 (Single) 2007
63.	Article	Bap31 enhances the ER export and quality control of human class I MHC molecules. J. Immunol. pp.6172-6181 (Collaboration) 2006
64.	Article	Characterization of cold- and high-pressure-active polygalacturonases from a deep-sea yeast Cryptococcus liquefaciens strain N6 Biochem. Biosci. Biotechnol pp.296-299 (Collaboration) 2006
65.	Article	Phylogenetic analysis of pectin-degrading yeasts from deep-sea environments J. Jpn. Soc. Extremophiles pp.21-26 (Collaboration) 2006
66.	Article	Systematic analysis of HSP genes on expression, cell growth and survival at high hydrostatic pressure in Saccharomyces cerevisiae Extremophiles pp.278-284 (Collaboration) 2006
67.	Article	Cloning and characterization of the rpoE gene encoding an RNA polymerase sigma E factor from the deep-sea piezophilic Shewanella violacea strain DSS12 DNA Sequence pp.69-74 (Collaboration) 2005
68.	Article	Enhanced production of isoamyl alcohol and isoamyl acetate by ubiquitination-deficient Saccharomyces cerevisiae mutants Cell. Mol. Biol. Lett. pp.383-388 (Collaboration) 2005
69.	Article	Identification of rpoBC genes encoding for beta and beta' subunits of RNA polymerase in a deep-sea piezophilic bacterium, Shewanella violacea strain DSS12 Biochem. Biosci. Biotechnol. pp.575-583 (Collaboration) 2005
70.	Article	Protein-DNA interactions under high-pressure conditions, studies with Capillary Narrow-tube Electrophoresis Biochem. Biosci. Biotechnol. pp.1415-1417 (Collaboration) 2005
71.	Article	Cloning and overproduction of the rpoZ Gene Encoding an RNA polymerase omega subunit from a deep-sea piezophilic Shewanella violacea strain DSS12 DNA Sequence pp.118-122 (Collaboration) 2004
72.	Article	Differential pressure resistance in the activity of RNA polymerase isolated from Shewanella violacea and Escherichia coli Extremophiles pp.367-375 (Collaboration) 2004
73.	Article	Effects of high hydrostatic pressure on the transcriptional activity of RNA polymerase of the deep-sea piezophilic bacterium Shewanella violacea DSS12 Proceedings for the 6th International Conference (IMBC) on Marine Biotechnology (Collaboration) 2004
74.	Article	Extremophiles: Pressure Microbial Diversity and Bioprospecting pp.154-159 (Collaboration) 2004
75.	Article	Multiple ubiquitin-specific protease genes are involved in degradation of yeast tryptophan permease Tat2 at high pressure FEMS Microbiol. Lett. pp.171-179 (Collaboration) 2004
76.	Article	Piezophysiology of yeast -Occurrence and significance Cell. Mol. Biol. pp.437-445 (Single) 2004
77.	Article	The N- and C-terminal mutations in tryptophan permease Tat2 confer cell growth in Saccharomyces cerevisiae under high-pressure and low-temperature conditions Extremophiles pp.143-149 (Collaboration) 2004
78.	Article	Pressure-induced differential regulation of the two tryptophan permeases Tat1 and Tat2 by ubiquitin ligase Rsp5 and its binding proteins, Bul1 and Bul2 pp.7566-7584 (Collaboration) 2003
79.	Article	The role of tryptophan permease Tat2 in cell growth of yeast under high-pressure condition Advances in High Pressure Bioscience and Biotechnology pp.271-274 (Single) 2003
80.	Article	Cytoskeletal adaptation of living mammalian cells surviving under extremely high hydrostatic pressure Trends in High Pressure Bioscience and Biotechnology pp.259-263 (Collaboration) 2002
81.	Article	Superoxide dismutase is involved in high tolerance to copper in the deep-sea yeast Cryptococcus sp. N6 Biotechnol. Lett. pp.1069-1074 (Collaboration) 2002
82.	Article	The biological significance of tryptophan availability on high-pressure growth in yeast Trends in High Pressure Bioscience Biotechnology pp.219-226 (Collaboration) 2002
83.	Article	Isolation of a highly copper-tolerant yeast, Cryptococcus sp., from the Japan Trench and the induction of superoxide dismutase activity by Cu2+ Biotechnol. Lett. pp.2027-2034 (Collaboration) 2001
84.	Article	Purification and characterization of novel extracellular endopolygalacturonases from a deep-sea yeast, Cryptococcus sp. N6, isolated from the Japan Trench. Biotechnol. Lett. Biotechnol. Lett. pp.1735-1739 (Collaboration) 2001
85.	Article	The biotechnological potential of piezophiles Trends Biotechnol. pp.102-108 (Collaboration) 2001
86.	Article	Metabolic changes in glycolysis in yeast induced by elevated hydrostatic pressure. -A study in baro-(piezo-)physiology Science and Technology of High-Pressure Research pp.335-337 (Collaboration) 2000
87.	Article	Tryptophan permease gene TAT2 confers high-pressure growth in Saccharomyces cerevisiae pp.8093-8102 (Collaboration) 2000
88.	Article	A new application of moderate hydrostatic pressure for efficient detection of living yeast by flow cytometry pp.507-510 (Collaboration) 1999
89.	Article	Barophysiology (Piezophysiology) Extremophiles in Deep-Sea Environments pp.227-248 (Collaboration) 1999
90.	Article	Pressure-regulated metabolism in microorganisms Trends Microbiol. pp.447-453 (Collaboration) 1999
91.	Article	A possible function of the yeast vacuole in cytoplasmic pH homeostasis under hydrostatic pressure High Pressure Biology and Medicine pp.38-43 (Single) 1998
92.	Article	Analysis of intracellular pH in the yeast Saccharomyces cerevisiae under elevated hydrostatic pressure: a study in baro-(piezo-) physiology Extremophiles pp.223-228 (Collaboration) 1998
93.	Article	Hydrostatic pressure enhances vital staining with carboxyfluorescein or carboxydichlorofluorescein in Saccharomyces cerevisiae: Efficient detection of labeled yeasts by flow cytometry Appl. Environ. Microbiol. pp.1139-1142 (Single) 1998
94.	Article	Vacuolar acidification in Saccharomyces cells in response to elevated hydrostatic pressure Rev High Pressure Science and Technology pp.1312-1314 (Collaboration) 1998
95.	Article	Antisense-mediated regulation of Annexin VII gene expression during the transition from growth to differentiation in Dictyostelium discoideum Gene pp.49-56 (Collaboration) 1997
96.	Article	Vacuolar acidification in Saccharomyces cerevisiae induced by elevated hydrostatic pressure is transient and is mediated by vacuolar H+-ATPase Extremophiles pp.89-93 (Collaboration) 1997
97.	Article	Yeast vacuoles may serve as proton sequestrants under high hydrostatic pressure High Pressure Research in the Bioscience and Biotechnology pp.209-212 (Collaboration) 1997
98.	Article	Vacuolar acidification under high hydrostatic pressure in Saccharomyces cerevisiae High Pressure Bioscience and Biotechnology pp.53-58 (Collaboration) 1996
99.	Article	Effect of hydrostatic pressure on the yeast vacuole High Pressure Science and Technology,pp.875-877 (Collaboration) 1995
100.	Article	Hydrostatic pressure promotes the acidification of vacuoles in Saccharomyces cerevisiae pp.307-312 (Collaboration) 1995
101.	Article	Specific expression of a gene encoding a novel calcium-binding protein, CAF-1, during transition of Dictyostelium cells from growth to differentiation Dev. Growth Differ. pp.39-48 (Collaboration) 1995
102.	Article	Precise expression of the cAMP receptor gene, CAR1, during transition from growth to differentiation in Dictyostelium discoideum FEBS Lett. pp.23-241 (Collaboration) 1994
103.	Article	Transition of starving Dictyostelium cells to differentiation phase at a particular position of the cell cycle Differentiation pp.169-175 (Collaboration) 1989
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